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fecal microbiota transplantation (Rambam Health Care Campus)

Development stage: Preclinical
Lead developer: Rambam Health Care Campus
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

Fecal microbiota transplantation (FMT) is an investigational live biotherapeutic therapy being developed by Rambam Health Care Campus for the eradication of carbapenem-resistant Enterobacteriaceae (CRE) colonization. [3] Delivered orally via capsules, this therapy introduces fecal material from a healthy donor to restore a healthy gut microbiome. [2, 3] The underlying mechanism is believed to be the competitive exclusion of pathogenic CRE by the newly introduced commensal microorganisms. [2] CRE are classified as an "urgent threat level" and are associated with high mortality rates (40-50%) in hospital-acquired infections. [3] This decolonization strategy aims to reduce an individual's risk of developing a CRE infection and to prevent the spread of these multi-drug resistant organisms in healthcare settings. [3]

Other names: fecal microbiota transplantFMT

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