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fecal microbiota transplantation (The Second Hospital of Nanjing Medical University)
- Development stage
- Unknown
- Lead developer
- The Second Hospital of Nanjing Medical University
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral, Rectal
01
Overview
Fecal microbiota transplantation (FMT) as standardized by The Second Hospital of Nanjing Medical University is a microbiome-based therapy used to treat moderate to severe ulcerative colitis. This specific protocol, often referred to as the "Nanjing strategy" or "Washed Microbiota Transplantation" (WMT), involves the preparation of a purified bacterial suspension from healthy donor stool using an automated washing process to reduce pro-inflammatory metabolites and improve safety. The suspension is delivered to the patient's mid-gut via gastroscopy or to the colon. The therapy aims to restore a healthy gut microbial ecosystem, thereby inducing clinical remission and mucosal healing by modulating the host's immune response and intestinal barrier function.
- Other names
- Standardized FMTfecal bacteriotherapyWashed Microbiota TransplantationWMT
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