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fecal microbiota transplantation + vedolizumab
- Development stage
- Unknown
- Lead developer
- McMaster University
- Modality
- Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Rectal, Intravenous
01
Overview
Fecal microbiota transplantation + vedolizumab is an investigational combination therapy developed by McMaster University for the treatment of active ulcerative colitis. This dual-action approach combines weekly fecal microbiota transplantation (FMT), administered via enema, with vedolizumab induction therapy. FMT is a biologic therapy that aims to restore gut microbiome diversity and address microbiota dysbiosis by transferring intestinal bacteria from healthy anonymous donors to patients. Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin, inhibiting leukocyte trafficking into the intestinal mucosa. The combination is specifically being studied in patients who have failed prior biologic therapies to determine if addressing both immune trafficking and microbial manipulation simultaneously leads to superior clinical outcomes.
- Other names
- FMT and Vedolizumab CombinationFecal Microbiota Transplantation and VedolizumabFMT and Vedolizumab Combination in UC
02
Targets
α4β7 (Integrin alpha-4 beta-7 heterodimer)
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