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Fecal Microbiota Transplantation capsules
- Development stage
- Phase 2
- Lead developer
- Assistance Publique des Hôpitaux de Paris
- Modality
- Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
This experimental intervention consists of oral capsules containing fecal microbiota derived from healthy donors, developed by the services of JC Lagier at Assistance Publique Hopitaux De Marseille. It is being evaluated for the treatment of resistant major depressive disorder in patients with schizophrenia. The therapy aims to modulate the gut-brain axis by restoring a healthy microbial balance in the gastrointestinal tract, which is hypothesized to alleviate depressive symptoms and improve overall mental health outcomes in this specific patient population. The treatment protocol typically involves a bowel lavage followed by the administration of multiple microbiota capsules.
- Other names
- microbiota capsulesFMT capsulesexperimental drug (Assistance Publique Hopitaux De Marseille)
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