Drug intelligence / Profile preview

Femiest

Development stage
Phase 4
Lead developer
Haupt Pharma
Modality
Small Molecules
Administration
Vaginal
01

Overview

Femiest is a low-dose vaginal estrogen therapy containing estradiol hemihydrate, equivalent to 10 mcg of 17β-estradiol. It is formulated as a vaginal tablet specifically designed for local administration to treat the genitourinary syndrome of menopause (GSM). The drug acts as a potent agonist of estrogen receptors in the vaginal and urethral tissues, promoting the maturation of the vaginal epithelium, improving tissue elasticity, and restoring a healthy vaginal pH. This localized action helps alleviate symptoms such as vaginal atrophy, dryness, dyspareunia, and various lower urinary tract symptoms (LUTS), including urgency and frequency, with minimal systemic absorption.

Brand names
Femiest
Other names
17beta-estradiol vaginal tabletestradiol hemihydrate vaginal tablet
02

Targets

ESR2 (ERβ)ESR1 (ERα)

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