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Fencamfamine is a central nervous system stimulant developed by Merck in the 1960s, originally as an appetite suppressant but later used primarily for treating depressive day-time fatigue, lack of concentration, and lethargy—especially in patients with chronic medical conditions due to its favorable safety profile. It acts mainly as an indirect dopamine agonist by inhibiting the dopamine transporter (DAT), thereby blocking reuptake and increasing synaptic concentrations of dopamine and norepinephrine. Fencamfamine also stimulates the release of these neurotransmitters. Unlike amphetamines, it does not inhibit monoamine oxidase enzymes, making it somewhat safer. Some evidence suggests involvement of opioid receptors in its activity. The drug is less potent than dexamphetamine and has a lower risk profile but can still cause dependence with prolonged use[1][2][3][4].
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