fendiline

Fendiline is a nonselective calcium channel blocker of the diphenylalkylamine class and acts as a coronary vasodilator. It was originally developed for its anti-anginal and antiarrhythmic properties in the management of coronary heart disease. Fendiline inhibits the influx of calcium ions into cardiac and vascular smooth muscle cells by blocking L-type calcium channels, leading to vasodilation—particularly in coronary arteries—and increased blood flow to the heart muscle. This alleviates ischemia and reduces angina symptoms. Additionally, it exhibits calmodulin antagonistic actions (inhibiting calmodulin-activated myosin light-chain kinase and phosphodiesterase), negative inotropic effects (reducing cardiac contractility), smooth muscle relaxation, cardioprotection, and has been shown to inhibit K-Ras plasma membrane localization—a mechanism relevant for certain cancers with KRAS mutations[2][3][5][8]. Fendiline has a slow onset of action and long half-life but is now clinically obsolete due to newer alternatives.

Brand names

SensitCordanSenzit

Other names

fendilinfendiline hydrochloridehydrochloride fendiline