Drug intelligence / Profile preview

fennel extract

Development stage
Unknown
Administration
Oral, Topical
01

Overview

Fennel extract is derived from the plant *Foeniculum vulgare* and is used in traditional and alternative medicines, commonly as an herbal or dietary supplement. It demonstrates diverse potential pharmacological effects, including **antispasmodic, anti-inflammatory, antioxidant, oestrogenic, anxiolytic, cytoprotective, hepatoprotective, antiulcerogenic, anticarcinogenic, memory-enhancing, hypoglycaemic, oculohypotensive, and antihirsutism effects**. These activities are due to its phytochemical content (notably anethole, fenchone, estragole, among others)[5]. Mechanistically, fennel extract's actions include **phytoestrogenic activity** (mimicking estrogenic effects), **modulation of gastrointestinal motility**, and **antioxidant defense**. Fennel extract is used as a herbal remedy for symptoms such as colic in infants, mild gastrointestinal discomfort (bloating, flatulence), menstrual cramps, cough, and indigestion; topical preparations have been studied for hirsutism and anti-aging effects[1][3][5]. It is not FDA-approved as a pharmaceutical drug, and there is notable variability in composition, efficacy, and safety between products.

Other names
fennelFoeniculum vulgare extractsweet fennel extractAnethum FoeniculumBari-SanufCarosellaFenouilFinnochioFoeniculi AntheroleumFoeniculumHinojoHuile de FenouilPhytoestrogenSanufShatapusphaXiao Hui Xiang
02

Targets

HDAC (HDAC family)STAT1 (Signal transducer and activator of transcription protein 1)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)DNMT (DNA methyltransferase)ESR1 (ERα)ESR2 (ERβ)

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