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fenoverine
- Development stage
- Phase 4
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Fenoverine is a phenothiazine-based small molecule antispasmodic agent primarily indicated for the treatment of irritable bowel syndrome and pain due to smooth muscle spasm. It acts as a non-anticholinergic synchronizer of smooth muscle motility by modulating the calcium gradient across muscular cell membranes—regulating both the influx of extracellular calcium and/or release from intracellular stores. This mechanism inhibits asynchronous spasmodic contractions without significantly affecting normal physiological motility in the intestine. Fenoverine does not act as a muscarinic or opiate-receptor antagonist[1][2][6][8]. It has been used in clinical trials for irritable bowel syndrome and is available under several brand names.
- Brand names
- SpasmoprivSyncrospas
- Other names
- fenoverinafenoverinum
02
Targets
CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)CaV3 (Caveolin-3)
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