Drug intelligence / Profile preview

Fenozolone

Development stage
Discontinued
Lead developer
Sanofi
Modality
Small Molecules
Administration
Oral
01

Overview

Fenozolone is a psychostimulant and psychoactive drug developed in the 1960s by Laboratoires Dausse. It is structurally related to pemoline and 4-methylaminorex, and acts primarily as a norepinephrine-dopamine releasing agent (NDRA), increasing the presynaptic release of norepinephrine, dopamine, and serotonin. This results in amphetamine-like stimulant effects on the central nervous system, enhancing monoaminergic neurotransmission. Fenozolone was used medically as a psychostimulant and antidepressant under the brand name Ordinator but has largely fallen out of clinical use due to safety concerns[1][4][5][7].

Brand names
Ordinator
Other names
fenozolonafenozolonumphenozolone2-(ethylamino)-5-phenyl-4(5H)-oxazolone2-(ethylamino)-4-oxo-5-phenyl-2-oxazoline15302-16-6
02

Targets

SERT (Sodium-dependent serotonin transporter)DAT (Dopamine plasma membrane transport protein)NET (Norepinephrine Transporter)

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