fentanyl + ibuprofen

This combination therapy involves the co-administration of intranasal fentanyl and oral ibuprofen. It is being studied by CHU Sainte-Justine for the management of acute pain in pediatric patients with suspected fractures in the emergency department. Fentanyl is a synthetic opioid that acts as a potent agonist at the mu-opioid receptor, offering rapid pain relief. Ibuprofen is a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes, which are responsible for the synthesis of prostaglandins that mediate pain and inflammation. The combination is designed to leverage the rapid onset of intranasal fentanyl with the longer duration of action of ibuprofen to provide consistent analgesia throughout an emergency department visit.

Other names

intranasal fentanyl + oral ibuprofenINF + ibuprofen