fentanyl + ketorolac (University of South Alabama)

Fentanyl + ketorolac is a multimodal analgesic combination utilized as the standard of care for managing postoperative pain in pediatric patients, specifically those undergoing bilateral myringotomy with tympanostomy tube (BMT) placement. This regimen combines fentanyl, a potent synthetic mu-opioid receptor agonist that provides rapid systemic analgesia, with ketorolac, a non-steroidal anti-inflammatory drug (NSAID) that inhibits cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) enzymes to reduce prostaglandin synthesis. In a Phase 4 clinical trial conducted by the University of South Alabama, this intramuscular combination is used as the active comparator to evaluate the efficacy and opioid-sparing potential of the Nerve of Arnold block regional anesthesia technique. The combination aims to provide effective pain control while balancing the side effects associated with opioid use in children.

Other names

IM fentanyl and ketorolacfentanyl/ketorolacfentanyl-University of South Alabama-postoperative pain