Drug intelligence / Profile preview

fentanyl + propofol + atracurium + isoflurane

Development stage
Unknown
Lead developer
Ain Shams University
Modality
Small Molecules
Administration
Intravenous, Inhalation
01

Overview

This anesthetic protocol refers to a specific combination of drugs used for the induction and maintenance of general anesthesia in a clinical trial conducted by Ain Shams University. The regimen involves an induction phase using **fentanyl** (a potent opioid analgesic), **propofol** (an intravenous sedative-hypnotic), and **atracurium** (a non-depolarizing neuromuscular blocker). Maintenance of anesthesia is achieved through the administration of **isoflurane** (a volatile inhalational anesthetic) delivered in an oxygen and air mixture, supplemented with intermittent doses of atracurium to maintain muscle relaxation. This protocol was specifically evaluated in the context of middle ear surgery to facilitate controlled hypotension and optimize the surgical field.

Other names
induction and maintenance of anaesthesia-Ain Shams UniversityInduction and maintenance of anaesthesia
02

Targets

Muscle-type nicotinic acetylcholine receptorMOR (Mu opioid receptor)GABRR (GABA-A receptor subunit rho)

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