fenticonazole

Fenticonazole is an imidazole antifungal drug primarily used topically as the nitrate salt for the treatment of vulvovaginal candidiasis and other superficial fungal infections. It exhibits a broad spectrum of activity against dermatophytes, yeasts (including Candida albicans), and some gram-positive bacteria such as Staphylococcus aureus. Fenticonazole also demonstrates antiparasitic action against Trichomonas vaginalis. Its mechanism of action involves inhibition of ergosterol synthesis—an essential component for fungal cell membrane integrity—by blocking fungal cytochrome P450-dependent enzymes that convert lanosterol to ergosterol. Additionally, it inhibits oxidizing enzymes (oxidases and peroxidases), leading to accumulation of toxic peroxides and necrosis in fungal cells. The drug also increases membrane permeability in bacteria and inhibits pyruvate oxido-reductase in protozoa, contributing to its antibacterial and antiprotozoal effects[1][3][6][7]. Fenticonazole is available in various topical formulations including creams, sprays, ovules, and vaginal capsules.

Brand names

LomexinGynoxinFentizol

Other names

fenticonazole nitrate