fentonium

Fentonium is a synthetic small molecule drug classified as an atropine derivative and a quaternary analog of hyoscyamine. It acts primarily as an anticholinergic, antispasmodic, and anti-ulcerogenic agent. Fentonium functions by blocking muscarinic acetylcholine receptors (antimuscarinic action), thereby inhibiting parasympathetic nerve impulses in smooth muscle, secretory glands, and the central nervous system. Additionally, it is reported to act as an allosteric blocker of α12βγε nicotinic receptors and can increase spontaneous acetylcholine release at the motor endplate without depolarizing muscle or inhibiting cholinesterase activity. Fentonium has been investigated for its effects on gastrointestinal disorders and opioid withdrawal symptoms in animal models[1][2][5][8][10].

Other names

fentonium bromide