Drug intelligence / Profile preview

fenugreek extract

Development stage
Phase 3
Lead developer
Gencor
Administration
Oral
01

Overview

Fenugreek extract is a concentrated preparation derived primarily from the seeds of Trigonella foenum-graecum, used as a dietary supplement for glycemic control, lactation support, lipid management, and other traditional indications. It contains steroidal saponins (e.g., protodioscin, dioscin), 4-hydroxyisoleucine, fibers, flavonoids, and other phytochemicals thought to contribute to effects such as slowing carbohydrate absorption, improving postprandial glycemia, and possible androgen-modulating and galactagogue activity. Evidence for lowering postprandial blood glucose is suggestive but mixed and of generally low quality; most other claimed uses lack high-quality confirmation. Safety concerns include gastrointestinal upset, hypoglycemia risk when combined with antidiabetic drugs, allergy (cross-reactivity with Fabaceae), potential interactions (e.g., warfarin potentiation, SSRIs with rare serotonin syndrome), and avoidance during pregnancy due to reported teratogenic risk at supplemental doses. It is not FDA-approved as a drug and is marketed as an herbal supplement.

Brand names
Testofen
Other names
fenugreek seed extractTrigonella foenum-graecum extractmethi extractFoenugraeci semen extractfenugreek
02

Targets

SHBG (Sex hormone-binding globulin)SRD5A (Steroid 5-alpha-reductase)CYP19A1 (Aromatase)AR (Adrenergic receptors)

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