Drug intelligence / Profile preview

fenugreek seed extract

Development stage
Phase 3
Lead developer
Gencor
Modality
Small Molecules
Administration
Oral
01

Overview

Fenugreek seed extract is a dietary supplement derived from the seeds of the plant Trigonella foenum-graecum. It has been used traditionally in various cultures for thousands of years as both a spice and herbal remedy. The extract contains bioactive compounds such as saponins (notably diosgenin), alkaloids, and flavonoids. Its proposed mechanisms include slowing glucose absorption in the gut and stimulating insulin secretion—effects that may help lower blood sugar levels in people with diabetes. Fenugreek also appears to have mild estrogenic activity and may modulate androgen receptors; these properties are thought to underlie its use for increasing libido and sexual function in both men (Testofen) and women (Libifem). Other traditional uses include alleviating menstrual cramps (dysmenorrhea), supporting lactation during breastfeeding, reducing cholesterol levels, aiding weight management, improving muscle performance parameters such as strength or lean mass gain (though evidence is limited), and treating digestive complaints like constipation or loss of appetite. Despite widespread use as a supplement for these indications—including diabetes management—robust clinical evidence remains limited or low quality for most uses[1][2][3][4][5][6][7].

Brand names
TestofenLibifem
Other names
fenugreekTrigonella foenum-graecumfenugreek seed powderGreek hay seedBockshornkleeMethi
02

Targets

ER (Estrogen receptor)AR (Adrenergic receptors)

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