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FeONPs-curcumin
- Development stage
- Preclinical
- Lead developer
- National Research Centre
- Modality
- Nanoparticles → Drug Delivery Systems, Small Molecules
- Administration
- Oral
01
Overview
**FeONPs-curcumin** is an experimental nanomedicine consisting of iron oxide nanoparticles capped with curcumin, a polyphenolic small molecule derived from *Curcuma longa*. The formulation is intended to improve curcumin delivery and bioavailability. In a reserpine-induced rat model of Parkinson's disease, FeONPs-Cur improved motor activity, restored dopamine and norepinephrine concentrations in the midbrain and striatum, reduced oxidative-stress markers, reduced elevated monoamine oxidase activity, and preserved acetylcholinesterase and sodium-potassium ATPase activity in selected brain regions. It remains an academic, preclinical antiparkinsonian candidate without a known sponsor-assigned development code, marketed brand, clinical trial program, or regulatory approval. ([ijbms.mums.ac.ir](https://ijbms.mums.ac.ir/article_23001.html))
- Other names
- FeONPs-CurFeONPs-curcumincurcumin-capped iron oxide nanoparticlesiron oxide nanoparticles capped with curcumin
02
Targets
AcetylcholinesteraseMAOA (Monoamine oxidase A)
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