Drug intelligence / Profile preview

fermented ginseng

Development stage
Preclinical
Lead developer
Ilhwa
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Fermented ginseng is a preparation of ginseng (Panax ginseng) that has been processed with microorganisms like yeast and lactic acid bacteria. [1, 6] This fermentation converts the primary active compounds, known as major ginsenosides (e.g., Rb1, Rg1), into minor, rarer ginsenosides such as Compound K (CK), Rh1, and Rg3. [1, 3, 12] This transformation significantly enhances the bioavailability and absorption of these active components, as the minor ginsenosides are smaller molecules that are more easily utilized by the body. [3, 8, 10] Fermented ginseng is investigated for numerous health benefits, including immunomodulatory effects, anti-fatigue, antioxidant, anti-inflammatory properties, and liver protection. [1, 4, 18] As noted in the provided context and supported by preclinical data, it is also being studied for its potential to improve conditions like nutritional anemia by promoting the formation of red blood cells. [9, 13, 20] It is typically marketed as a nutraceutical or dietary supplement. [21]

Brand names
Legenseng
Other names
发酵人参fermented red ginseng
02

Targets

CYP2C9 (Cytochrome P450 family 2 subfamily C member 9)PPARA (Peroxisome proliferator-activated receptor alpha)ABCB1 (P-glycoprotein)PPARG (Peroxisome proliferator-activated receptor gamma)CYP1A2 (Cytochrome P450 1A2)CYP3A4 (Cytochrome P450 3A4)NF-κB

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