Drug intelligence / Profile preview

fermented red ginseng

Development stage
Preclinical
Lead developer
Ilhwa
Administration
Oral
01

Overview

**Fermented red ginseng** is a fermented **Panax ginseng** derived botanical preparation used as a dietary supplement and nutraceutical rather than a conventional pharmaceutical drug. In the provided preclinical literature, fermented red ginseng was studied orally in a high-fructose diet rat model and showed improvement in obesity-related metabolic abnormalities, including dyslipidemia, hypertension, fatty liver, endothelial dysfunction, and insulin resistance, with greater activity than non-fermented red ginseng. Its proposed mechanism is pleiotropic and not attributable to a single defined molecular target; reported effects include downregulation of endothelin-1 and vascular adhesion molecules together with upregulation of insulin receptor substrate 1 and glucose transporter type 4 in muscle, consistent with metabolic, anti-inflammatory, antioxidant, and vasoprotective activity. No specific commercial developer, manufacturer, approved drug status, or standardized pharmaceutical product identity is established from the provided evidence.

Other names
fermented red ginseng extractfermentated red ginseng
02

Targets

IRS1 (Insulin receptor substrate 1)ET-1 (Endothelin-1)SLC2A4 (Solute carrier family 2 facilitated glucose transporter member 4)

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