Drug intelligence / Profile preview

ferric pyrophosphate

Development stage
Approved
Lead developer
Rockwell Medical
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules
Administration
Intravenous
01

Overview

Ferric pyrophosphate is an iron replacement product used primarily to treat or prevent iron deficiency anemia, especially in patients with chronic kidney disease who are on hemodialysis. It works by providing bioavailable iron for erythropoiesis (red blood cell production), helping maintain hemoglobin levels. Ferric pyrophosphate forms a strong complex with the ligand, allowing efficient delivery of elemental iron into circulation and incorporation into hemoglobin. Its unique formulation allows for parenteral administration during dialysis sessions and is associated with fewer gastrointestinal side effects compared to some other oral or intravenous iron salts. In addition to medical use, it is also employed as a food fortificant and dietary supplement due to its high bioavailability and minimal impact on taste or color[1][2][6][9].

Brand names
TrifericTriferic AVNUActiferol FeSunactive Fe
Other names
ferric pyrophosphate citrateiron(III) pyrophosphateiron pyrophosphatediphosphoric acid, iron(3+) salt (3:4)ferric pyrophosphate nonahydrate
02

Targets

FTL (Ferritin light chain)

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