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Ferritarg P is a rabbit polyclonal antibody engineered to recognize acidic ferritin, a protein found at elevated levels in cancer cells. It functions by binding to these ferritin antigens, and when labeled with radionuclides such as Yttrium-90 (90Y), it delivers localized radiation to cancer cells, causing DNA damage and ultimately cell death. It has also been used with Indium-111 (111In) for diagnostic imaging. Ferritarg P received orphan drug designation from the European Union in 2003 and the United States FDA in 2006 for Hodgkin's disease. Developed by MAT Biopharma, its clinical advancement has been stalled since 2008.
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