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ferroquine
- Development stage
- Phase 2
- Lead developer
- Sanofi
- Modality
- DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules
- Administration
- Oral, Subcutaneous (investigational/animal Studies)[5]
01
Overview
Ferroquine is a synthetic organometallic antimalarial drug structurally related to chloroquine but distinguished by the incorporation of a ferrocene moiety. It was developed as part of efforts to overcome resistance to traditional aminoquinoline antimalarials. Ferroquine acts primarily as a hemozoin inhibitor, disrupting the detoxification pathway of heme in Plasmodium parasites. It has demonstrated potent activity against both chloroquine-susceptible and chloroquine-resistant strains of Plasmodium falciparum and P. vivax[4][5]. The drug has been evaluated in multiple phase II clinical trials for uncomplicated malaria but development for this indication was discontinued after phase II[4][5]. Ferroquine is also being investigated for potential repositioning as an anticancer agent[3].
- Other names
- ferrochloroquineferrocene-quinoline conjugate
02
Targets
β-Hematin
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