ferrostatin-1

Ferrostatin-1 is a synthetic, small molecule and the first-in-class selective inhibitor of ferroptosis, a regulated form of iron-dependent cell death characterized by the accumulation of lipid peroxides[1][3][5]. Its mechanism of action is as a radical-trapping antioxidant (RTA), effectively suppressing lipid peroxidation by neutralizing lipid reactive oxygen species (ROS) and thereby preventing membrane oxidative damage and cell death[1][2][3][4][11]. Ferrostatin-1 has been widely employed as a research tool to study and modulate ferroptotic pathways in disease models, including neurodegeneration, cancer, ischemic injury, and various organ toxicities[3][9]. It is not approved for human therapeutic use and is intended solely for research purposes[5][7]. Ferrostatin-1 has an IC50 of approximately 60 nM in inhibiting erastin-induced ferroptosis in cellular assays[3][5]. Because of its rapid metabolism and poor pharmacokinetics, it is primarily a tool compound[6].

Other names

ethyl 3-amino-4-(cyclohexylamino)benzoateCAS 347174-05-4CAS347174-05-4CAS-347174-05-4