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Iron sulfate dihydrate (ferrous sulfate dihydrate) is a small molecule mineral supplement used primarily for the treatment and prevention of iron-deficiency anemia. As an oral iron salt, it provides elemental iron in the ferrous (Fe²⁺) state, which is readily absorbed in the gastrointestinal tract and utilized as a critical component of hemoglobin, myoglobin, and various heme-containing enzymes. In clinical practice, it serves as a standard oral therapy to replenish iron stores and support erythropoiesis. Recent clinical investigations, such as Phase 4 trials in Spain, have evaluated its efficacy compared to intravenous iron in reducing perioperative blood transfusions and improving hemoglobin levels in patients undergoing revascularization for chronic lower limb ischemia associated with peripheral artery disease.
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