Drug intelligence / Profile preview

Fertifol

Development stage
Unknown
Lead developer
Effik
Modality
Small Molecules
Administration
Oral
01

Overview

Fertifol is a pharmaceutical-grade folic acid (Vitamin B9) supplement developed by Effik, specifically formulated at a 400 µg dose for women during the preconception period and the first trimester of pregnancy. Its primary indication is the primary prevention of neural tube defects (NTDs), such as spina bifida and anencephaly, in the developing fetus. Folic acid is a critical cofactor in one-carbon metabolism, where it is converted into tetrahydrofolate derivatives essential for the synthesis of purines and pyrimidines (DNA and RNA) and the methylation of homocysteine to methionine. Adequate folate levels are vital for the rapid cell division and tissue growth that occur during early embryogenesis.

Brand names
Fertifol
Other names
folic acidvitamin B9pteroylglutamic acid
02

Targets

FOLR1 (FRα)FOLR2 (Folate receptor beta)DHFR (Dihydrofolate reductase)

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