fesoterodine + fluconazole

Fesoterodine + fluconazole is a combination of two small molecule drugs used together primarily when both indications are present or in cases where drug-drug interactions are relevant. Fesoterodine is an antimuscarinic agent indicated for the treatment of overactive bladder with symptoms such as urge urinary incontinence, urgency, and frequency. It acts as a prodrug that is rapidly converted to its active metabolite 5-hydroxymethyl tolterodine (5-HMT), which exerts antimuscarinic effects by antagonizing muscarinic acetylcholine receptors in the bladder[3][6]. Fluconazole is a triazole antifungal agent used to treat systemic and superficial fungal infections including candidiasis; it works by inhibiting fungal cytochrome P450 enzyme 14α-demethylase, thereby disrupting ergosterol synthesis and compromising fungal cell membrane integrity[1][4]. When co-administered, there may be pharmacokinetic interactions due to fluconazole’s moderate inhibition of CYP3A4; however, clinical studies suggest no significant dose adjustment for fesoterodine is required unless potent CYP3A4 inhibitors are also involved[2][5].

Other names

FesoterodinaFESO