festuca elatior pollen extract, depigmented polymerized

festuca elatior pollen extract, depigmented polymerized is an allergen immunotherapy (AIT) product developed by LETI Pharma. It consists of pollen extracts from Meadow Fescue (Festuca elatior) that have undergone a depigmentation process to remove non-allergenic components like pigments and flavonoids, followed by polymerization with glutaraldehyde. This chemical modification creates 'allergoids,' which exhibit significantly reduced IgE-binding capacity, thereby lowering the risk of systemic allergic reactions during administration. Despite the reduced allergenicity, the extract retains its immunogenicity, stimulating T-cell responses and inducing the production of allergen-specific IgG4 antibodies to promote long-term clinical tolerance. It is primarily indicated for the treatment of allergic rhinoconjunctivitis and allergic asthma triggered by grass pollen.

Brand names

Depigmoid

Other names

Meadow fescue pollen extract, depigmented polymerizedSchedonorus pratensis pollen extract, depigmented polymerized