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Drug intelligence / Profile preview
fevipiprant + montelukast
- Development stage
- Phase 2
- Lead developer
- Novartis
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Fevipiprant (QAW039)** is a potent, selective antagonist of the prostaglandin D2 receptor 2 (DP2/CRTh2) developed for the treatment of moderate to severe asthma, particularly in patients with eosinophilic inflammation. **Montelukast** is a leukotriene receptor antagonist used for the chronic prophylaxis and treatment of asthma and to relieve symptoms of allergic rhinitis. The combination **fevipiprant + montelukast** is not an approved commercial product but has been investigated in clinical trials to test the additive or synergistic effects on asthma control, with both drugs targeting distinct inflammatory pathways implicated in asthma pathophysiology[1][2][3][4].
- Other names
- fevipiprant + montelukastQAW039 + montelukast
02
Targets
ALOX12 (Arachidonate 12-lipoxygenase, 12S type)ALPL (Tissue-nonspecific alkaline phosphatase)CYSLTR1 (Cysteinyl-leukotriene type 1 receptor)PTGDR2 (Prostaglandin D2 receptor 2)UreaseSucrase-Isomaltase
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