Drug intelligence / Profile preview

FG-3180

Development stage
Phase 1
Lead developer
FibroGen
Modality
Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Small Molecules
Administration
Intravenous
01

Overview

FG-3180 is a CD46-targeted positron emission tomography (PET) imaging agent developed for the diagnosis of solid tumors. It is composed of a radiolabeled antibody targeting CD46, enabling enhanced PET imaging to detect and assess tumors expressing this antigen. The drug is intended as a diagnostic radiopharmaceutical to aid in patient selection and monitoring in oncology, particularly prostate cancer. It is being developed by Fortis Therapeutics and FibroGen. The mechanism of action involves enhancing PET imaging through specific binding to CD46 on tumor cells.

Other names
89Zr-DFO-YS5FG-3180FG3180FG 3180
02

Targets

CD46 (CD46 Molecule)

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