FG-9041

FG‑9041 (also known as DNQX) is a synthetic small molecule belonging to the quinoxaline class. It acts as a potent and selective competitive antagonist of non-NMDA ionotropic glutamate receptors—specifically AMPA and kainate receptors—and also inhibits certain NMDA receptor subtypes. It is widely used in molecular neuroscience research to dissect the roles of excitatory amino acid neurotransmission in synaptic physiology and pathophysiology. In animal models (notably rats), it has been shown to reduce electroconvulsive shock-induced impairment of learning and memory. The compound is not approved for clinical use or marketed for any therapeutic indication[1][2][3][4].

Other names

FG 9041FG9041FG-9041dnqxUNII-62T278S1MXUNII62T278S1MXUNII 62T278S1MXSR-01000075442SR01000075442SR 01000075442Tocris 0189Tocris0189Tocris-0189