FGF-trap

FGF-trap is a soluble decoy receptor designed to sequester members of the fibroblast growth factor (FGF) family, thereby preventing their interaction with native cell-surface receptors. The specific construct described in preclinical research is a recombinant fusion protein consisting of the extracellular ligand-binding domain of fibroblast growth factor receptor 2 (FGFR2) fused to the Fc portion of an immunoglobulin. By binding and neutralizing FGF ligands such as FGF-2 (basic FGF) and FGF-7 (keratinocyte growth factor), FGF-trap disrupts critical paracrine signaling pathways in the tumor microenvironment that drive angiogenesis and epithelial cell proliferation. In studies of cervical carcinogenesis, FGF-trap has been shown to significantly reduce microvessel density, effectively impairing the angiogenic phenotype. In experimental settings, it is often delivered systemically via an adenoviral vector (Ad-FGF-trap) to achieve sustained expression of the soluble decoy.

Other names

FGFR2-FcFGFR-2-FcFGFR 2-Fcsoluble FGFR2-Fc fusion proteinAdenovirus FGF-trap