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fgfr1 antisense oligonucleotide
- Development stage
- Preclinical
- Modality
- Antisense Oligonucleotides (ASOs) → Long RNA Therapeutics → RNA Therapeutics → Nucleic Acid Therapeutics, Modified DNA Oligonucleotides → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics, Single-strand DNA → Antisense DNA → DNA Therapeutics → Nucleic Acid Therapeutics
01
Overview
An fgfr1 antisense oligonucleotide is a phosphorothioate-modified antisense oligonucleotide designed to inhibit the expression of fibroblast growth factor receptor 1 (FGFR1). By binding to FGFR1 mRNA, it reduces the production of the FGFR1 protein and its high-affinity bFGF binding sites. This mechanism has shown to suppress the growth of human glioblastoma-derived cell lines, suggesting its potential as a targeted therapy for malignant astrocytomas where FGFR1 overexpression contributes to proliferation.
02
Targets
FGFR1 (Fibroblast growth factor receptor 1)
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