FGFR2 shRNA

FGFR2 shRNA is a short hairpin RNA-based therapeutic candidate designed to silence the expression of fibroblast growth factor receptor 2 (FGFR2). It specifically targets the common exon of the FGFR2 IIIb and IIIc isoforms, which are frequently overexpressed in pancreatic ductal adenocarcinoma (PDAC). By inducing RNA interference (RNAi), the shRNA reduces FGFR2 mRNA and protein levels, leading to the inhibition of downstream MAPK/ERK signaling pathways. This suppression results in decreased cancer cell proliferation and reduced expression of vascular endothelial growth factor A (VEGF-A), thereby inhibiting angiogenesis. Research conducted at Nippon Medical School has demonstrated its efficacy in reducing tumor growth in preclinical models of pancreatic cancer.

Other names

FGFR2 short hairpin RNAFGFR-2 short hairpin RNAFGFR 2 short hairpin RNAFGFR2-shRNAFGFR-2-shRNAFGFR 2-shRNA