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FH-006 + adebrelimab + apatinib
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Fc-Fusion Proteins → Carrier/Scaffold Proteins → Recombinant Proteins and Enzymes, Small Molecules, Monoclonal Antibodies → Antibody-Based Therapeutics
- Administration
- Intravenous, Oral
01
Overview
FH-006 + adebrelimab + apatinib is an investigational combination therapy developed by Jiangsu Hengrui Medicine for the treatment of non-small cell lung cancer (NSCLC). The regimen integrates three distinct therapeutic approaches: FH-006, a recombinant humanized IL-15/IL-15Rα-Fc fusion protein that acts as an IL-15 agonist to promote the proliferation and activation of T cells and natural killer (NK) cells; adebrelimab (SHR-1316), a humanized monoclonal antibody targeting programmed cell death ligand 1 (PD-L1) to restore anti-tumor immune responses; and apatinib (BP102), a small molecule tyrosine kinase inhibitor that selectively inhibits vascular endothelial growth factor receptor 2 (VEGFR-2) to block tumor angiogenesis. By combining cytokine-driven immune stimulation, immune checkpoint inhibition, and anti-angiogenic effects, the triplet therapy aims to overcome resistance mechanisms and improve clinical outcomes in patients with advanced or metastatic lung cancer.
- Brand names
- AiruikaAiTan
- Other names
- AdebrelimabApatinibApatinib mesylate
02
Targets
VEGFR2 (Vascular endothelial growth factor receptor 2)EGFR T790M (Epidermal growth factor receptor T790M mutant)CD274 (Programmed cell death protein 1 ligand 1)B7-H3
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