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FH-006 + adebrelimab + bevacizumab + cisplatin + carboplatin
- Development stage
- Unknown
- Lead developer
- Hengrui Pharmaceutical
- Modality
- Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous
01
Overview
This combination therapy is an investigational regimen developed by Jiangsu HengRui Medicine for the treatment of lung cancer. It consists of FH-006, a recombinant humanized monoclonal antibody targeting the PVRIG (PVR-related immunoglobulin domain-containing protein) immune checkpoint; adebrelimab (SHR-1316), a monoclonal antibody targeting the PD-L1 (Programmed death-ligand 1) checkpoint; BP102, a bevacizumab biosimilar that inhibits VEGF (Vascular Endothelial Growth Factor) to suppress tumor angiogenesis; and the platinum-based chemotherapeutic agents cisplatin and carboplatin, which act as DNA alkylators to induce cytotoxic effects. By combining multiple immune checkpoint inhibitors with anti-angiogenic therapy and traditional chemotherapy, this regimen aims to maximize anti-tumor responses and overcome resistance mechanisms in lung cancer patients.
- Brand names
- Airuika
- Other names
- FH-006 + SHR-1316 + BP102 + cisplatin + carboplatin
02
Targets
B7-H3VEGFA (Vascular endothelial growth factor A)CD274 (Programmed cell death protein 1 ligand 1)DNAEGFR T790M (Epidermal growth factor receptor T790M mutant)
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