Drug intelligence / Profile preview

ficus deltoidea extract

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral, Topical
01

Overview

Ficus deltoidea extract is a botanical extract derived from the leaves or other parts of the plant *Ficus deltoidea*, a small shrub native to Malaysia and Southeast Asia. Traditionally used in Malay medicine to relieve headache, fever, toothache, and as a postpartum tonic, scientific research now supports its medicinal potential. Notably, the extract has demonstrated *antihyperglycemic* (antidiabetic), *antioxidant*, *anticancer*, *antihypertensive*, *anti-inflammatory*, *antimicrobial*, *wound-healing*, and *anti-aging* properties. Mechanistically, the extract stimulates insulin secretion (via K^+^ ATP channel-dependent and independent pathways), enhances glucose uptake in adipocytes (via insulin-mimetic and insulin-sensitizing actions), augments adiponectin secretion, and reduces intestinal glucose absorption (by inhibiting sucrase). It also directly scavenges free radicals and upregulates the body's antioxidant enzymes (superoxide dismutase, catalase, glutathione peroxidase). The major bioactive components include flavonoids (such as vitexin and isovitexin), triterpenoids, saponins, and tannins, with much of the pharmacological activity attributed to these compounds. Research is ongoing into its use as a natural antioxidant, antidiabetic supplement, and potentially as an anticancer and sexual health agent[1][2][3][4][5][6][7].

Other names
mistletoe fig extractdelta fig extractFD extract
02

Targets

NeuraminidaseMisfolded SOD1ADIPOQ (Adiponectin)GPX4 (Glutathione peroxidase 4)INSR (Insulin receptor)KATP channel (ATP-sensitive potassium channel)

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