Drug intelligence / Profile preview

ficus hirta vahl

Development stage
Preclinical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Ficus hirta Vahl, also known as 'Wuzhi Maotao', is a traditional botanical drug and medicinal plant belonging to the Moraceae family. It has been utilized for centuries in traditional Chinese medicine and other Asian medical systems to treat a variety of ailments, including indigestion, respiratory conditions (such as cough, asthma, and pneumonia), liver diseases, and inflammatory disorders like arthritis. The plant extract contains a complex mixture of bioactive metabolites, primarily flavonoids, phenylpropanoids, and terpenoids. These components contribute to its diverse pharmacological profile, which includes immune-modulating, anti-inflammatory, antioxidant, and hepatoprotective activities. Notably, research has identified CD36 as a key biological target through which Ficus hirta Vahl regulates lipid metabolism and inflammation, particularly in the context of non-alcoholic fatty liver disease (NAFLD). Toxicological assessments have confirmed the safety and non-toxicity of the extract for medicinal use.

Other names
Wuzhi MaotaoFicus hirta
02

Targets

CD36 (CD36 antigen)

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