filociclovir

Filociclovir is a second-generation methylene cyclopropane compound and a purine nucleoside analogue with broad-spectrum antiviral activity. It acts primarily as a DNA-directed DNA polymerase inhibitor and ganciclovir kinase inhibitor. Filociclovir is structurally related to guanosine and functions by inhibiting viral replication through interference with viral DNA polymerases. It has demonstrated potent in vitro activity against human cytomegalovirus (HCMV), being approximately ten times more effective than ganciclovir without increased cytotoxicity. The drug is under development for the treatment of cytomegalovirus infections and has also shown activity against other herpesviruses such as HHV-6 and HHV-8[1][3][4][9].

Other names

filociclovircyclopropavir