FIN56

FIN56 is a small molecule and a well-characterized, specific inducer of ferroptosis—a form of regulated, iron-dependent cell death. Its mechanism involves promoting the degradation of glutathione peroxidase 4 (GPX4), a key lipid repair enzyme, and activation of squalene synthase, leading to depletion of coenzyme Q10 and lethal accumulation of lipid hydroperoxides. In preclinical studies, FIN56 demonstrates anti-tumor effects in cancer models by inducing ferroptosis and synergizes with autophagy-related processes, supporting its use as a tool compound for cancer research and potentially for therapeutic development in ferroptosis-sensitive malignancies[1][2][3][4][6][7][8].

Other names

1,3,8-trihydroxy-6-methylanthracen-9(10H)-one