Drug intelligence / Profile preview

finasteride + minoxidil

Development stage
Preclinical
Lead developer
XYON Health
Modality
Small Molecules
Administration
Topical
01

Overview

Finasteride + minoxidil (brand name: SiloxysSystem™ Gel) is a compounded topical combination therapy developed by XYON Health for the treatment of androgenetic alopecia (male and female pattern hair loss). The formulation utilizes XYON's proprietary SiloxysSystem™ Gel technology, a controlled-release, liposomal drug delivery system that employs a silicone polymer 3D mesh to trap liposomes on the scalp surface. This system is designed to maximize local drug exposure to hair follicles while significantly reducing systemic absorption and the associated risk of side effects. Finasteride acts as a 5-alpha reductase inhibitor, blocking the conversion of testosterone to dihydrotestosterone (DHT), the primary hormone responsible for hair follicle miniaturization. Minoxidil acts as a vasodilator and potassium channel opener, stimulating hair follicles and enhancing scalp circulation. As a compounded medication, it is not FDA-approved as a combination product but is prescribed by licensed physicians using already-approved active pharmaceutical ingredients.

Brand names
SiloxysSystem Gel
Other names
Topical Finasteride & Minoxidil in SiloxysSystem GelFinasteride/minoxidil combination
02

Targets

SRD5A2 (Steroid 5-alpha-reductase type II)SRD5A1 (Steroid 5-alpha-reductase type 1)SUR2B (Sulfonylurea receptor 2B)

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