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finasteride + tadalafil (Veru Inc.)
- Development stage
- Unknown
- Lead developer
- Veru
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**Aitingjie** is an oral fixed-dose capsule containing **finasteride 5 mg** and **tadalafil 5 mg** for treatment of benign prostatic hyperplasia. Finasteride inhibits type 2 5-alpha-reductase, reducing conversion of testosterone to dihydrotestosterone and thereby decreasing androgen-driven prostate growth. Tadalafil inhibits phosphodiesterase type 5, increasing cyclic GMP signaling and relaxing smooth muscle in the prostate, bladder neck, and lower urinary tract. The product was approved and marketed in China by Taienkang's subsidiary Shandong Huabokai Biotechnology as a domestic generic version of Veru's Entadfi. ([tai-kang.com.cn](https://tai-kang.com.cn/news/2311.html))
- Brand names
- AitingjieEntadfi爱廷列
- Other names
- Finasteride + Tadalafil Capsulesfinasteride + tadalafil非那雄胺他达拉非胶囊
02
Targets
SRD5A1 (Steroid 5-alpha-reductase type 1)PDE6 (Phosphodiesterase 6)PDE5A (cGMP-specific 3',5'-cyclic phosphodiesterase 5A)SRD5A2 (Steroid 5-alpha-reductase type II)
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