Drug intelligence / Profile preview

FIPI

Development stage: Preclinical
Lead developer: Stony Brook University
Modality: Small Molecules
Administration: Intraperitoneal

Overview

FIPI (5-fluoro-2-indolyl des-chlorohalopemide) is a potent, cell-permeable, and reversible small molecule inhibitor of phospholipase D1 (PLD1) and phospholipase D2 (PLD2). Derived from the antipsychotic drug halopemide, FIPI lacks dopaminergic activity and specifically targets the PLD enzymes to inhibit the hydrolysis of phosphatidylcholine into phosphatidic acid and choline. This inhibition disrupts downstream oncogenic signaling pathways involved in cell proliferation, survival, and migration. Preclinical research, including studies presented at AACR 2024, indicates that FIPI can reduce pancreatic carcinogenesis, attenuate tumor growth, and inhibit acinar-to-ductal metaplasia in mouse models of pancreatic ductal adenocarcinoma (PDAC). It is widely utilized as a research tool to investigate the therapeutic potential of PLD inhibition in oncology and inflammatory diseases.

Other names: 5-fluoro-2-indolyl des-chlorohalopemide

Targets

PLD1 (Phospholipase D1)PLD2 (Phospholipase D2)

Beyond the preview

Go deeper on FIPI.

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Clinical trials

Follow clinical development from study design and recruitment through results.

Trial phase
Status
Readouts

Indications & development

Explore development by indication, patient population, and geography.

Indications
Development status
Countries

Licensing & deals

Trace asset ownership, licensing agreements, and commercial partnerships.

Partners
Deal terms
Milestones

Patents & exclusivity

Explore the patent landscape and regulatory exclusivity around an asset.

Patents
Expiration dates
Exclusivity

Competitive landscape

Compare development programs by target, modality, and indication.

Competing assets
Targets
Development stage

Research & analysis

Connect source evidence and development news to your research questions.

Publications
News
Analysis

Bring the full picture into focus.

See how Gosset can support your research on FIPI.

Explore the full profile