Drug intelligence / Profile preview

fisetin

Development stage
Phase 4
Lead developer
Bonerge Lifescience
Modality
Small Molecules
Administration
Oral
01

Overview

Fisetin is a naturally occurring plant flavonol from the flavonoid group of polyphenols. It is found in various fruits and vegetables such as strawberries, apples, persimmons, onions, and cucumbers[2][6]. Fisetin acts as an antioxidant and anti-inflammatory agent and has been studied for its potential roles as a DNA topoisomerase inhibitor and geroprotector[1][4]. Laboratory research suggests it may have neuroprotective properties and possible senolytic activity (removal of senescent cells), with some studies indicating it is more potent than quercetin in this regard[5]. However, there is no clinical evidence supporting health benefits in humans as of 2018[2].

Other names
非瑟酮5-desoxyquercetin3,3',4',7-tetrahydroxyflavone2-(3,4-dihydroxyphenyl)-3,7-dihydroxy-4H-chromen-4-onefisetholzsuperfustelungarischesgelbholzCotinus coggygria extractviset
02

Targets

TOP (DNA topoisomerases)SYK (Spleen Tyrosine Kinase)

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