Drug intelligence / Profile preview

fish oil concentrate

Development stage
Approved
Modality
Small Molecules
Administration
Oral, Intravenous
01

Overview

Fish oil concentrate is a dietary supplement and nutraceutical product derived from the oils of certain types of fish. It is rich in omega-3 polyunsaturated fatty acids—primarily eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA)—which are essential nutrients not synthesized by the human body and must be obtained through diet or supplementation. Fish oil concentrate is used primarily to lower triglyceride levels in adults with severe hypertriglyceridemia as an adjunct to diet and exercise. It also has anti-inflammatory properties and may provide benefits for cardiovascular health by reducing risk factors such as high cholesterol and blood pressure. Other studied uses include management of rheumatoid arthritis symptoms and support for eye health. The mechanism of action involves decreasing hepatic production of triglycerides via inhibition of diacylglycerol acyltransferase activity among other effects[2][4][5][6][9].

Brand names
LovazaOmacorOcean Blue OmegaMagna Omega-3TrikloCardio Omega BenefitsAnimi-3Animi3Animi 3DivistaDry Eye Omega Benefits
Other names
omega-3 polyunsaturated fatty acidsomega3 polyunsaturated fatty acidsomega 3 polyunsaturated fatty acidsomega-3 PUFAomega3 PUFAomega 3 PUFAN3 fatty acidsN-3 fatty acidsN 3 fatty acidsW3 fatty acidsW-3 fatty acidsW 3 fatty acidsEPA (fish oils)DHA (docosahexaenoic acid)eicosapentaenoic acid (EPA)marine oilsmenhaden oilshark liver oil
02

Targets

PPARD (Peroxisome proliferator–activated receptor delta)FFAR4 (Free fatty acid receptor 4)PPARG (Peroxisome proliferator-activated receptor gamma)FXR (Farnesoid x-activated receptor)PTGS2 (Prostaglandin-Endoperoxide Synthase 2)DGAT2 (Hepatic diacylglycerol acyltransferase 2)PPARA (Peroxisome proliferator-activated receptor alpha)

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