Drug intelligence / Profile preview

fish oil triglycerides

Development stage
Approved
Lead developer
Fresenius Kabi
Modality
Lipid-based Nanoparticles → Nanoparticles → Drug Delivery Systems
Administration
Intravenous
01

Overview

**Fish oil triglycerides** is a sterile intravenous lipid emulsion marketed as **Omegaven** by Fresenius Kabi. It is a fish oil-based source of calories and essential fatty acids containing long-chain omega-3 polyunsaturated fatty acids, principally eicosapentaenoic acid and docosahexaenoic acid. The product is approved in the United States for pediatric parenteral nutrition-associated cholestasis. In the completed Aalborg University Hospital Phase 2 hemodialysis study, a high-n-3 fatty-acid lipid emulsion was evaluated for acute effects on heart-rate variability, ventricular repolarization, and ventricular arrhythmias as markers of sudden cardiac-death risk. The proposed antiarrhythmic mechanism is rapid elevation of circulating free omega-3 fatty acids, which may alter myocardial membrane electrical stability rather than act through one defined drug receptor. ([accessdata.fda.gov](https://www.accessdata.fda.gov/drugsatfda_docs/label/2025/210589s005lbl.pdf))

Brand names
Omegaven
Other names
Omegaven 10%omega-3 fish oil lipid emulsionomega3 fish oil lipid emulsionomega 3 fish oil lipid emulsionhigh n-3 polyunsaturated fatty acid lipid emulsion
02

Targets

PPARA (Peroxisome proliferator-activated receptor alpha)NaV (Voltage-gated sodium channels)PPARG (Peroxisome proliferator-activated receptor gamma)Hepatic very-low-density lipoprotein (VLDL) synthesis and secretion machineryCACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)

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