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five-flavor sophora flavescens enteric-coated capsules + glutamine
- Development stage
- Unknown
- Lead developer
- Peking University First Hospital
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
This combination therapy consists of five-flavor sophora flavescens enteric-coated capsules and glutamine, typically administered alongside warm-water sitz baths for the treatment of radiation-induced proctitis. The five-flavor sophora flavescens capsule is a Traditional Chinese Medicine (TCM) formulation containing *Sophora flavescens* (Kushen) as a primary ingredient, which is rich in alkaloids like matrine and oxymatrine known for their anti-inflammatory and mucosal-healing properties. Glutamine is an amino acid that serves as a critical metabolic fuel for enterocytes and colonocytes, supporting the repair and regeneration of the intestinal mucosa damaged by pelvic radiotherapy. This specific regimen is being evaluated in clinical trials led by Peking University First Hospital for patients exhibiting significant rectal toxicity (RTOG grades >2) following radiation treatment.
- Brand names
- Wu Wei Ku Shen Chang Rong Jiao Nang
- Other names
- Five-Flavor Sophora Flavescens CapsulesWuwei Kushen enteric-coated capsules
02
Targets
TNFA (Tumor necrosis factor alpha (soluble))IL1B (Interleukin-1 beta)
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