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Fizurex
- Development stage
- Preclinical
- Lead developer
- Steel Therapeutics
- Modality
- Small Molecules, Transdermal Patches → Device-based Delivery → Drug Delivery Systems, Hydrogel Systems → Drug Delivery Systems
- Administration
- Topical
01
Overview
Fizurex is a **patent-pending, single-use, disposable wipe** intended as a more convenient, consistent, and patient-friendly formulation of a **combination therapy containing nifedipine and lidocaine**, designed for the treatment of **anal fissures**. This combination has been widely compounded and used off-label in cream formulations, where it is thought to work by **increasing blood flow and relaxing the anal sphincter**, thereby promoting healing. Fizurex aims to bring this established therapy to a wider population in a regulated, GMP-compliant, and standardized format suitable for FDA approval. The product is currently in preclinical development and preparing for Investigational New Drug (IND) submission, with planned progression to clinical trials[1][3][4][5][7][8].
- Brand names
- Fizurex
02
Targets
CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)NaV (Voltage-gated sodium channels)
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