Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
flavokawain A
- Development stage
- Preclinical
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Flavokawain A (FKA) is a natural chalcone constituent derived from the kava plant (*Piper methysticum*). It is being investigated for its therapeutic potential in chronic kidney disease (CKD) and various malignancies due to its anti-inflammatory, antioxidant, and anti-fibrotic properties. FKA acts by inhibiting the NF-κB signaling pathway and downregulating matrix metallopeptidase 9 (MMP9), which leads to a reduction in extracellular matrix (ECM) markers such as fibronectin and transforming growth factor β1 (TGF-β1). In preclinical models of CKD, FKA has demonstrated the ability to attenuate renal fibrosis and improve kidney function. Additionally, FKA is widely studied in oncology for its ability to induce apoptosis and inhibit proliferation in bladder, prostate, and breast cancer cells.
- Other names
- flavokawain AFKA
02
Targets
ERKMMP9 (Matrix metalloproteinase-9)NFKB1 (NF-κB1)
Beyond the preview
Go deeper on flavokawain A.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on flavokawain A.