flavone acetic acid

Flavone acetic acid is a synthetic flavonoid compound investigated primarily as an anticancer agent. It exhibits vascular targeting properties and has demonstrated antiproliferative effects on endothelial cells, likely through a superoxide-dependent mechanism that alters tumor vasculature permeability[1][5]. Preclinical studies showed unique antitumor activity, including the ability to induce regression of slow-growing solid tumors in mice by causing vascular collapse prior to tumor regression[5][7]. The precise mechanism of action remains unclear but may involve direct cytotoxicity at high concentrations, immunomodulatory effects (such as stimulation of natural killer cell activity and induction of interferon alpha), and dramatic reduction in tumor blood flow[7]. Flavone acetic acid has been evaluated in phase I clinical trials for cancer but did not demonstrate objective responses in patients[2][3].

Other names

flavone-8-acetic acidflavone8-acetic acidflavone 8-acetic acid